Hyperadrenocorticism is a disorder involving the adrenal glands or the pituitary gland. The end result is overproduction of a group of hormones called glucocorticoids. This disease is caused by and adrenal tumor, a pituitary tumor, or is mimicked by the prolonged administration of cortisone or related drugs. This syndrome is known as iatrogenic hyperadrenocorticism.

There are some breeds that commonly develop hyperadrenocorticism. Poodles and Dachshunds are frequently affected, but the disease can also occur in many other purebred and mixed breed dogs. The age of these dogs ranges from 6 months to 17 years but usually occur between 8-12 yrs.

Symptoms include increased thirst and urination, increased appetite, abdominal enlargement, obesity, muscle loss and weakness, lethargy, hair loss, thin skin, increased panting, mineralization of the skin, diabetes mellitus.

Diagnosis of this disease is accomplished through physical examination and laboratory work. A complete blood count, chemistry panel and urinalysis are the first tests recommended. Patients with this disease often have high blood sugar, cholesterol and liver enzymes, along with a low blood urea nitrogen. A complete blood count will show a stress response. Neutrophilia without a left shift and a lymhopenia with a monocytosis and a eosinopenia. Radiographs may be recommended to evaluate the size of the liver an adrenal glands. If there is evidence of hyperadrenocorticism from the lab work, tests necessary to confirm the diagnosis are necessary. Depending on the severity of the symptoms, this can involve urine testing or adrenal suppression tests.

If your pet is diagnosed with with hyperadrenocorticism, several treatments are available. Medical treatment with a drug called Mitotane (op-DDD) is often recommended. This drug selectively suppresses the adrenal gland to decrease production of glucocorticoid hormones. Side effects may include decreased appetite, vomiting and diarrhea.

Recently a new drug has been introduced, with some pretty astounding results. The name is Vetoryl chemical name is trilostane, Vetoryl contains the active ingrediant trilostane, which blocks the excessive production of cortisol. Daily administration of Vetoryl can greatly reduce the clinical signs associated with Cushing's syndrome, enhancing the quality of life for both dog and owner. Most of the time a diagnosis of hyperadrenocorticism, means extensive testing, multiple trips to the veterinarian and often times less than expected results. I think this new drug is going to be a godsend to Veterinarians and pet owners alike, ask your vet about this new drug if your dog has been diagnosed with Cushing's. This is a very complicated disease and if you have any other questions please do not hesitate to ask using our Ask the Veterinarian Form.